What is indometacin used for?
What is indometacin used for?
Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate acute pain and relieve symptoms of arthritis (osteoarthritis and rheumatoid arthritis) or gout, such as inflammation, swelling, stiffness, and joint pain.
Which heterocyclic ring is present in indomethacin?
NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlorobenzoyl)25-methoxy-2-methylindole-3-acetic acid.
What is indomethacin ER 75 mg used for?
Indomethacin is used to relieve pain, swelling, and joint stiffness caused by arthritis, bursitis, and tendonitis. Reducing these symptoms helps you do more of your normal daily activities. The sustained release capsule does not relieve pain quickly.
Is indomethacin 50 mg a narcotic?
If you experience any mental health changes, including anxiety, while taking this medication, contact your provider. Is indomethacin (Indocin) a controlled substance? No, indomethacin (Indocin) is not a controlled substance.
What type of ring structure is present in indomethacin?
A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively.
What is structure of indomethacin?
C19H16ClNO4Indomethacin / Formula
Is indomethacin stronger than ibuprofen?
Indocin and ibuprofen provide similar pain relief when used in arthritis patients. 6 A study that compared the drugs found that they were similarly effective, but patients preferred Indocin, although the study authors did not say why.
What is the mechanism of action of indomethacin?
Mechanism of Action Indomethacin functions like most other NSAIDs. The effects of indomethacin occur because it inhibits the synthesis of prostaglandins. Prostaglandins are produced primarily by cyclooxygenase (COX) enzymes, and prostaglandins are critical mediators of inflammation, fever, and pain.
Why is indomethacin used for PDA?
Indomethacin is indicated for patent ductus arteriosus (PDA) closure, as it promotes closure of the PDA and generally has an onset of action within minutes. Prostaglandins, especially E-type prostaglandins, maintain the patency of the ductus.
What is Indomethacin?
Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID). Indomethacin works by reducing hormones that cause inflammation and pain in the body.
When should indomethacin be avoided in patients with a recent mi?
Avoid the use of Indomethacin capsules in patients with a recent MI unless the benefits are expected to outweigh the risk of recurrent CV thrombotic events. If Indomethacin capsules are used in patients with a recent MI, monitor patients for signs of cardiac ischemia.
Does indomethacin undergo appreciable enterohepatic circulation?
Indomethacin undergoes appreciable enterohepatic circulation. About 60% of an oral dose is recovered in urine as drug and metabolites (26% as Indomethacin and its glucuronide), and 33% is recovered in feces (1.5% as Indomethacin). The mean half-life of Indomethacin is estimated to be about 4.5 hours.
Can indomethacin capsules increase the risk of cardiovascular events?
NSAIDs, including Indomethacin Capsules, can lead to new onset of hypertension or worsening of preexisting hypertension, either of which may contribute to the increased incidence of CV events.