What is the TPOX locus?
What is the TPOX locus?
Alleles at the TPOX STR locus have 6-14 different numbers of a four-nucleotide (AATG) repeat motif arranged in tandem. Although tri-allelic genotypes are generally rare, the TPOX tri-allelic pattern has a higher frequency, varying widely among populations.
What chromosome is TPOX on?
Chr 2
TPOX
| Other Names | Chromosomal Location | GenBank Accession |
|---|---|---|
| hTPO, TPO UniSTS: 240638 | 2p25.3; intron 10 of human thyroid peroxidase gene Chr 2; 1.472 Mb (May 2004, NCBI build 35) | M68651; has 11 repeats |
What is D21S11 gene?
Segregation studies of Alzheimer’s disease (AD) gene and a cloned DNA probe (D21S11), which detects an EcoRI restriction fragment length polymorphism for a sequence located in the medial part of the long arm of chromosome 21, are reported in a large pedigree, in which AD is transmitted as an autosomal dominant …
What does SE33 mean on a DNA test?
SE33 is localized on chromosome 6 (2), consists of 32 alleles ranging between 227-316 bp including a variety of microvariants, and is comprised of a complex repeat sequence of AAAG (3). The comparatively low rate of stutter and high degree of polymorphism (1) make it an ideal candidate for forensic applications.
What does TPOX mean?
Within the combined DNA index system (CODIS), five STRs are located within genes: TH01 (human tyrosine hydroxylase), TPOX (human thyroid peroxidase), vWA (von Willebrand factor), CSF1PO (c-fms protooncogene for CSF-1 receptor gene), and FGA (human alpha fibrinogen).
How many alleles does TPOX?
Alleles at the TPOX STR locus have 6–14 different numbers of a four-nucleotide (AATG) repeat motif arranged in tandem.
What does D5S818 mean?
The D5S818 locus represents a typical VNTR consisting of a 4-basepair repeat element of homogeneous AGAT sequence [4]. In preliminary studies, an RFLP for the enzyme SnaB1 was discovered upstream from the tandem array due to a C/T polymorphism (hereafter called the À 13 SNP).
What is D3S1358?
So that’s what it means when you get a “D3S1358, 17/18”. You have 17 repeats on one chromosome and 18 on the other at D3S1358, a certain spot on a chromosome. The two numbers come from the fact that we all have two copies of each of our chromosomes* .
How are STR loci named?
The STR locus is named as, for example, D3S1266, where D represents DNA, 3 means chromosome 3 on which the STR locus locates, S stands for STR, and 1266 is the unique identifier. On the basis of different repeat units, STRs can be classified into different types.
What does a DNA test say when you are not the father?
If the tested father is not the child’s biological father, the results will be exclusion of paternity. The probability of paternity in this case would be 0% and the Statement of Results on the report will read “The alleged father is excluded as the biological father of the tested child.
What DNA markers are used in paternity testing?
DNA PROFILES In this case the alleles are simply measures of short tandem repeats (STR) on the gene. One of these STR alleles comes from a person’s father, one from their mother. In a DNA paternity test, the analysis seeks matches of allele number values between the alleged father and child.