Which of these proteins is a Bcl-2 family member?
Which of these proteins is a Bcl-2 family member?
The BCL-2 family is divided into three groups based on their primary function (1) anti-apoptotic proteins (BCL-2, BCL-XL, BCL-W, MCL-1, BFL-1/A1), (2) pro-apoptotic pore-formers (BAX, BAK, BOK) and (3) pro-apoptotic BH3-only proteins (BAD, BID, BIK, BIM, BMF, HRK, NOXA, PUMA, etc.).
What do Bcl-2 family members control?
Bcl-2 family members are Ced-9 homologues. They control cell death by regulating the cytochrome c release from the mitochondria. Among them, Bcl-2 and Bcl-xL inhibit cell death. In contrast, there are members (Bax, Bak, Bid, and Bad) that promote cell death.
What do Bcl-2 family proteins have in common?
Bcl-2 family proteins have a general structure that consists of a hydrophobic α-helix surrounded by amphipathic α-helices. Some members of the family have transmembrane domains at their c-terminus which primarily function to localize them to the mitochondrion.
What type of gene is Bcl-2?
BCL2 (BCL2 Apoptosis Regulator) is a Protein Coding gene. Diseases associated with BCL2 include Follicular Lymphoma and High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit. Among its related pathways are Hedgehog signaling pathway and Autophagy.
Are BAX and Bak Bcl-2 proteins?
Two key members of the Bcl-2 family are the proapoptotic proteins Bax and Bak, which convert from harmless monomers into deadly oligomers that form pores in the MOM.
How do Bcl-2 family proteins regulate apoptosis in mammalian cells?
Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 1999; 399:483–7. Cheng EH, Sheiko TV, Fisher JK, et al. VDAC2 inhibits BAK activation and mitochondrial apoptosis.
Is BCL2 a proto oncogene or tumor suppressor gene?
The proto-oncogene bcl2 is a known suppressor of apoptosis (programmed cell death), resulting in a long life for the involved cells.
What does BCL2 stand for?
B-Cell Leukemia/Lymphoma 2
BCL2 (B-Cell Leukemia/Lymphoma 2)
Is Bcl-2 a protein?
A protein that helps control whether a cell lives or dies by blocking a type of cell death called apoptosis. The gene for BCL2 is found on chromosome 18, and transfer of the BCL2 gene to a different chromosome is seen in many B-cell leukemias and lymphomas.
Are Bax and Bak Bcl-2 proteins?
What is BAX and Bak?
Bax and Bak are members of the Bcl-2 family and core regulators of the intrinsic pathway of apoptosis. Upon apoptotic stimuli, they are activated and oligomerize at the mitochondrial outer membrane (MOM) to mediate its permeabilization, which is considered a key step in apoptosis.