How does thioguanine work as a chemotherapy drug?

How does thioguanine work as a chemotherapy drug?

Thioguanine is used to treat acute myeloid leukemia (AML; a type of cancer that begins in the white blood cells). Thioguanine is in a class of medications known as purine analogs. It works by slowing or stopping the growth of cancer cells in your body.

Is 6-thioguanine an anticancer drug?

Drug type: 6-Thioguanine is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug.

Is 6-mercaptopurine toxic?

While 6-MP is generally well-tolerated, some patients suffer from significant side effects such as gastrointestinal (GI) toxicity, including hepatitis, hypoglycemia, nausea, and pancreatitis, which can substantially limit the tolerated dose of 6-MP.

What is the mechanism of action of 6-mercaptopurine?

The anticancer drug 6-mercaptopurine (6-MP) inhibits de novo purine synthesis and acts as an antiproliferative agent by interfering with protein, DNA and RNA synthesis and promoting apoptosis.

Is thioguanine an immunosuppressant?

Abstract. Azathioprine, 6-mercaptopurine, and 6-thioguanine are immunosuppressive drugs indicated in the prevention of graft rejection, and treatment of auto-immune disease or inflammatory bowel disease. Their anti-nucleotidic properties are also used for the treatment of acute leukaemia.

Does thioguanine cause diarrhea?

Rare side effects You might have one or more of them. They include: bowel problems which can cause severe stomach ache, being sick, diarrhoea and fever. severe liver damage when used with other chemotherapy drugs, oral contraceptives and alcohol.

Is mercaptopurine a chemotherapy drug?

Mercaptopurine is a chemotherapy drug mainly used to treat acute lymphoblastic leukaemia (ALL). It can also be used to treat acute myeloid leukaemia (AML) and acute promyelocytic leukaemia (a rare form of AML).

Is there a cure for hairy cell leukemia?

There is no cure for hairy cell leukemia. But treatments are effective at putting hairy cell leukemia in remission for years.

Is mercaptopurine cytotoxic?

6-mercaptopurine is an active cytotoxic agent for use only under the direction of physician experienced in the administration of such agents. Immunisation using a live organism vaccine has the potential to cause infection in immunocompromised hosts.

What are the side effects of mercaptopurine?

Side Effects

  • Black, tarry stools.
  • clay colored stools.
  • cough or hoarseness.
  • decreased appetite.
  • fever or chills.
  • nausea, vomiting.
  • pinpoint red spots on the skin.
  • rash, itchy skin.

Is thioguanine an thiopurine?

Thioguanine (TG) is a thiopurine which has been used for patients with inflammatory bowel disease (IBD), who have failed azathioprine (AZA) or mercaptopurine (MP) due to adverse events or suboptimal response. Its widespread use has been hampered due to concerns about nodular regenerative hyperplasia (NRH) of the liver.

What are thioguanine nucleotides?

Background: Thioguanine nucleotides (TGNs) are the active product of thiopurine metabolism. Levels have been correlated with effective clinical response. Nonetheless, the value of TGN monitoring in clinical practice is debated.