What is the pathology of rheumatoid arthritis?
What is the pathology of rheumatoid arthritis?
Rheumatoid arthritis is characterized by the presence of autoantibodies known as rheumatoid factors (RF) and anti-citrullinated peptide antibodies (ACPA, which includes the anti-cyclic citrullinated peptide antibody or anti-CCP). Rheumatoid factors have been long recognized as a feature of many patients with RA.
What is rheumatoid arthritis PDF?
Rheumatoid arthritis is an autoimmune inflammatory disease primarily characterized by synovitis which is accompanied by extra-articular organ involvement, such as interstitial pneumonia, in addition to clinical symptoms including pain, swelling, stiffness of multiple joints, fever, and malaise.
What causes rheumatoid arthritis pathophysiology?
Genetic factors and immune system abnormalities contribute to disease propagation. CD4 T cells, mononuclear phagocytes, fibroblasts, osteoclasts, and neutrophils play major cellular roles in the pathophysiology of RA, whereas B cells produce autoantibodies (ie, rheumatoid factors).
What are the 3 stages of rheumatoid arthritis?
Stages of rheumatoid arthritis
- Stage 1. Stage 1 is early stage RA. Many people feel joint pain, stiffness, or swelling.
- Stage 2. Stage 2 is moderate-stage RA.
- Stage 3. Once RA has progressed to stage 3, it’s considered severe.
- Stage 4. At stage 4, there’s no longer inflammation in the joint.
Is there different types of rheumatoid arthritis?
The two main types of rheumatoid arthritis (RA) are seropositive and seronegative RA, with juvenile RA being another type that only affects children.
Which cells have a major role in the pathophysiology of rheumatoid arthritis?
Among them, T cells (5) and macrophages (6) are recognized as two critical cellular components involved in RA. The essential role of T cells in the pathogenesis of RA has been validated, including studies on the infiltration of synovial T cells in inflammatory synovium of RA (7).