Can you live with Gardner syndrome?
Can you live with Gardner syndrome?
Outlook / Prognosis Gardner syndrome can be a life-limiting diagnosis in some cases. Without treatment, nearly all people with the condition will develop colon cancer at some point.
How long do people live with Gardner syndrome?
The average age at diagnosis is 25 years; average life expectancy for untreated patients is 45 years. The disease is characterized by various soft tissue tumors; colorectal adenomas; and multiple osteomas, particularly of the skull.
Does Gardner’s syndrome have supernumerary teeth?
Dental abnormalities are present in around 30% of patients with Gardner syndrome, and may include supernumerary teeth, compound odontomas, hypodontia, abnormal tooth morphology and impacted or unerupted teeth.
How is Gardner’s syndrome treated?
Gardner’s syndrome treatment Medications such as an NSAID (sulindac) or a COX2 inhibitor (celecoxib) may be used to help limit the growth of colon polyps. Treatment also involves close monitoring of the polyps with lower GI tract endoscopy to make sure they do not become malignant (cancerous).
How many people have Gardner syndrome?
The prevalence of Gardner syndrome is 1 per one million people within the United States, with an incidence of 1 in 8000 individuals. Most commonly, Gardner syndrome patients present with epidermoid cysts.
What are the signs and symptoms of Gardner’s syndrome?
Disease at a Glance Other signs and symptoms of Gardner syndrome include dental abnormalities; osteomas (benign bone growths); various skin abnormalities such as epidermoid cysts, fibromas (a benign tumor of the connective tissue), and lipomas; and desmoid tumors.
How common is Gardner’s syndrome?
In the United States, one person per million population is diagnosed with Gardner syndrome. The incidence of FAP is 1 case per 8000 people.
How do you get Gardner syndrome?
What causes Gardner syndrome? Gardner Syndrome is due to mutations on the APC gene on chromosome 5q22. The gene plays a role in tumour suppression. Gardner syndrome is inherited as an autosomal dominant trait so that an affected person has a 50% chance of passing on the gene to each of their children.
What are characteristics of Gardner syndrome?
Gardner syndrome, a variant of familial adenomatous polyposis (FAP), is an autosomal dominant disease characterized by GI polyps, multiple osteomas, and skin and soft tissue tumors. Cutaneous findings of Gardner syndrome include epidermoid cysts, desmoid tumors, and other benign tumors.
Is Gardner syndrome dominant or recessive?
Gardner syndrome, a variant of familial adenomatous polyposis (FAP), is an autosomal dominant disease characterized by GI polyps, multiple osteomas, and skin and soft tissue tumors.