What are the 6 subtypes of triple-negative breast cancer?
What are the 6 subtypes of triple-negative breast cancer?
performed gene expression profiling of tumor samples from 587 TNBC patients and divided TNBC into six subtypes: basal-like 1 (BL1), basal-like 2 (BL2), mesenchymal (M), mesenchymal stem-like (MSL), immunomodulatory (IM), and luminal androgen receptor (LAR) [13].
What are the molecular subtypes of breast cancer?
Breast cancer has four primary molecular subtypes, defined in large part by hormone receptors (HR) and other types of proteins involved (or not involved) in each cancer: Luminal A or HR+/HER2- (HR-positive/HER2-negative) Luminal B or HR+/HER2+ (HR-positive/HER2-positive) Triple-negative or HR-/HER2- (HR/HER2-negative)
Are there different types of triple-negative breast cancer?
They classified TNBC tumors into the following four distinct subtypes: (1) LAR, (2) mesenchymal (MES), (3) basal-like immunosuppressed (BLIS), and (4) basal-like immune-activated (BLIA).
What are molecular subtypes?
Molecular subtyping of cancer, as its name suggests, is a new way to classify cancers into different groups based on molecular data and classification models. Contrary to the traditional histological classification of cancer, molecular classifications rely on biomarkers and classifiers.
Is triple-negative breast cancer considered metastatic?
Every cancer diagnosis is unique, but in general, triple-negative breast cancer is a more aggressive type of tumor with a faster growth rate, higher risk of metastasis and recurrence risk.
Is chemo always needed for triple-negative breast cancer?
Triple-negative breast cancer (TNBC) doesn’t have estrogen or progesterone receptors and also makes too little or none of the HER2 protein. Because the cancer cells don’t have these proteins, hormone therapy and drugs that target HER2 are not helpful, so chemotherapy (chemo) is the main systemic treatment option.
What molecular subtype of breast cancer is most common?
The breast cancer subtype HR+/HER2- is the most common subtype with an age-adjusted rate of 87.4 new cases per 100,000 women, based on 2015–2019 cases.
What is the most aggressive subtype of breast cancer?
Abstract. Triple negative breast cancer (TNBC) is a more aggressive subtype of breast cancer and is characteristic of the absence of the expressions of estrogen receptor, progesterone receptor, and human epithelial growth factor receptor 2 in breast tumor tissues.
What is luminal B subtype?
Advertisement. Luminal B-like breast cancer is estrogen-receptor-positive and HER2-positive and has any level of Ki-67 and may be progesterone receptor-positive or progesterone receptor-negative. Luminal B cancers tend to grow faster than luminal A cancers and have a slightly worse prognosis.
What is luminal A subtype?
Luminal-A subtype is defined as ER-positive and/or PR-positive tumors with negative HER2 and low Ki67 (proliferating cell nuclear antigen) index by immunohistochemistry[14]. Patients with luminal-A breast cancer have a good prognosis; the relapse rate is significantly lower than the other subtypes.