What are the clinical signs and symptoms of vaso-occlusive disorders?

What are the clinical signs and symptoms of vaso-occlusive disorders?

You may also have:

  • Breathing problems (shortness of breath or pain when breathing or both)
  • Extreme tiredness.
  • Headache or dizziness.
  • Painful erections in males.
  • Weakness or a hard time moving some parts of your body.
  • Yellowish skin color (jaundice)

What is Hyperhemolytic crisis?

Introduction: Hyperhemolytic crisis is a rare and dangerous complication of sickle cell disease where the hemoglobin level drops rapidly. This can quickly lead to organ failure and death. In the literature, most cases of hyperhemolysis in sickle cell patients followed a red cell transfusion.

Which manifestations of Vasoocclusive crisis are associated with sickle cell disease SCD in children?

The most common clinical manifestation of SCD is vaso-occlusive crisis. A vaso-occlusive crisis occurs when the microcirculation is obstructed by sickled RBCs, causing ischemic injury to the organ supplied and resultant pain.

What are the most common clinical features of sickle cell anemia in children?

Signs and symptoms can include:

  • Anemia. Sickle cells break apart easily and die.
  • Episodes of pain. Periodic episodes of extreme pain, called pain crises, are a major symptom of sickle cell anemia.
  • Swelling of hands and feet.
  • Frequent infections.
  • Delayed growth or puberty.
  • Vision problems.

How is vaso-occlusive crisis diagnosis?

Diagnosis. Diagnosis of vaso-occlusive crisis is based on clinical manifestations, complete blood count with white blood cell differential, platelet count, reticulocyte count, and comprehensive metabolic panel with liver and kidney function tests.

How do you know if your child has sickle cell?

Sickle cell disease usually is found at birth with a blood test during routine newborn screening tests. A second blood test (called a hemoglobin electrophoresis) will confirm the diagnosis.

What is the difference between sickle cell anemia and sickle cell disease?

Sickle cell disease (SCD) is a serious group of conditions which are inherited (genetic). It affects the red blood cells in the blood. Sickle cell anaemia is the name of a specific form of SCD in which there are two sickle cell genes (see below).

How do you treat Hyperhaemolysis?

Patients with hyperhaemolysis should be treated with intravenous immunoglobulin (IVIg) and IV Methylprednisolone. Additional transfusion has been associated with increasing haemolysis and worsening anaemia, and should be avoided if possible.

What are the symptoms of hemolysis?

Possible symptoms may include :

  • paleness.
  • fatigue.
  • dizziness.
  • heart palpitations.
  • jaundice.
  • headache.
  • enlarged spleen.
  • enlarged liver.

What are the symptoms of sickle cell in a child?

What are the symptoms of sickle cell disease in a child?

  • Anemia. This is the most common symptom.
  • Yellowing of the skin, eyes, and mouth (jaundice). This is a common symptom.
  • Pain crisis, or sickle crisis.
  • Acute chest syndrome.
  • Splenic sequestration (pooling).

What are triggers of vaso-occlusive crisis?

Triggers of vaso-occlusive crisis include the following: Hypoxemia: May be due to acute chest syndrome or respiratory complications. Dehydration: Acidosis results in a shift of the oxygen dissociation curve. Changes in body temperature (eg, an increase due to fever or a decrease due to environmental temperature change)