What is CD103 dendritic cells?
What is CD103 dendritic cells?
CD103+ dendritic cells (DCs) in nonlymphoid organs exhibit two main functions: maintaining tolerance by induction of regulatory T cells and protecting against tissue infection through cross-presentation of foreign antigens to CD8+ T cells.
What is CD103?
CD103 is a transmembrane heterodimer complex that mediates cell adhesion, migration, and lymphocyte homing of cell through interaction with E-cadherin.
What is the function of CD11c?
CD11c has been proposed to function in phagocytosis, cell migration, and cytokine production by monocytes/macrophages as well as induction of T cell proliferation by Langerhans cells. Using assays to quantify CD11c-mediated cell adhesion, we demonstrate that CD11c recognizes ICAM-2 and VCAM-1.
How the dendritic cells regulate the immune response?
Dendritic cells (DCs) represent a heterogeneous family of immune cells that link innate and adaptive immunity. The main function of these innate cells is to capture, process, and present antigens to adaptive immune cells and mediate their polarization into effector cells (1).
Where are plasmacytoid dendritic cells?
Plasmacytoid dendritic cells (pDCs) resemble antibody-secreting plasma cells and are believed to arise from a lymphoid progenitor. pDCs are found in blood and in lymphoid tissues such as lymph nodes, tonsils, spleen, thymus, and Peyer’s patches.
What are CD11c positive cells?
CD11c is a type I transmembrane protein that is expressed on monocytes, granulocytes, a subset of B cells, dendritic cells, and macrophages and may be demonstrated on B-cell chronic lymphocytic leukemia, marginal zone lymphomas, and hairy cell leukemia.
Are macrophages CD11c positive?
M1 macrophages were identified as F4/80-positive/CD11c-positive/CD206-negative and M2 macrophages were identified as F4/80-positive/CD11c-negative/CD206-positive.
What is dendritic cell and its function?
(den-DRIH-tik sel) A special type of immune cell that is found in tissues, such as the skin, and boosts immune responses by showing antigens on its surface to other cells of the immune system. A dendritic cell is a type of phagocyte and a type of antigen-presenting cell (APC).