What is Tetrazole reaction?
What is Tetrazole reaction?
The most common used synthesis of tetrazole derivatives is the 1,3-dipolar cycloaddition reaction between nitriles and azides (azide ion or hydrazoic acid, Scheme 2). 104−114. It was first described by Hantzsch and Vagt115 in 1901 through a [2 + 3] cycloaddition of an azide to a nitrile (Scheme 2).
What is Staudinger ligation?
Of interest in chemical biology research, the Staudinger ligation is a modification of the classical Staudinger reaction in which an electrophilic trap (usually a methyl ester) is placed on the triaryl phosphine.
What are the reagent for Staudinger reaction?
Mechanism of the Staudinger Reaction. Triphenylphosphine reacts with the azide to generate a phosphazide, which loses N2 to form an iminophosphorane. Aqueous work up leads to the amine and the very stable phosphine oxide.
What is an azide group?
Azide is the anion with the formula N−3. It is the conjugate base of hydrazoic acid HN 3. N−3 is a linear anion. Organic azides are organic compounds with the formula RN 3, containing the azide functional group. The dominant application of azides is as a propellant in air bags.
What is tetrazole used for?
Tetrazoles as antihypertensive agents Some tetrazole-containing drugs such as losartan, valsartan, irbesartan and candesartan have already been used for the treatment of hypertension in clinical practice, demonstrating the potential of tetrazole derivatives as putative antihypertensive drugs [17].
Is tetrazole acidic or basic?
The acidic nature of tetrazole is similar to corresponding carboxylic acids, but there is a difference in annular tautomerism of ring tetrazoles to carboxylic acids. The acidic nature of tetrazole is mainly affected by substitution compound nature at C-5 position.
What is aza Wittig reaction?
Aza-Wittig reactions are similar to Wittig reactions in that they also involve the reaction of a phosphonium ylide, in this case an iminophosphorane (or phosphinimide) such as 39, with a carbonyl group containing compound to form the carbon–nitrogen double bond of an imine along with a byproduct phosphine oxide such as …
What is azide used for?
Sodium azide is used as a chemical preservative in hospitals and laboratories. Accidents have occurred in these settings. In one case, sodium azide was poured into a drain, where it exploded and the toxic gas was inhaled (breathed in). Sodium azide is used in agriculture (farming) for pest control.
What does azide mean in chemistry?
azide, any of a class of chemical compounds containing three nitrogen atoms as a group, represented as (-N3).
How does TMS work in the brain?
Single or paired pulse TMS causes neurons in the neocortex under the site of stimulation to depolarize and discharge an action potential. If used in the primary motor cortex, it produces muscle activity referred to as a motor evoked potential (MEP) which can be recorded on electromyography.
What is the mechanism of action of a magnetic stimulation device?
Mechanism of action. Transcranial magnetic stimulation is achieved by quickly discharging current from a large capacitor into a coil to produce pulsed magnetic fields between 2 and 3 T. By directing the magnetic field pulse at a targeted area of the brain, one can either depolarize or hyperpolarize neurons in the brain.
What are the different types of TMS devices?
Some devices can provide magnetic fields that can penetrate deeper, are used for deep transcranial magnetic stimulation (deep TMS), and have different types of coils including the H-coil the C-core coil, and the circular crown coil; as of 2013 the H coil used in devices made by Brainsway were the most developed.