What is the function of claudin?
What is the function of claudin?
Claudins are tetraspan transmembrane proteins of tight junctions. They determine the barrier properties of this type of cell-cell contact existing between the plasma membranes of two neighbouring cells, such as occurring in endothelia or epithelia.
What is the difference between claudin and occludin?
Claudin (CLDN), occludin (OCLN) and junction adhesion molecule A (JAM-A) are transmembrane proteins, whereas zona occludens 1 (ZO-1) is a cytoplasmic plaque protein. CLDNs are integral transmembrane proteins (4), containing four transmembrane domains and two extracellular loops.
What is Zonula Occludens?
Abstract. ZO (zonula occludens) proteins are scaffolding proteins providing the structural basis for the assembly of multiprotein complexes at the cytoplasmic surface of intercellular junctions. In addition, they provide a link between the integral membrane proteins and the filamentous cytoskeleton.
How many Claudins are there?
24
The claudin family consists of 24 known transmembrane proteins exhibiting distinct tissue- and development-specific distribution patterns [37, 38].
What is macula Occludens?
There are four main types of cell-cell junctions: Three are different types of connecting junctions, that bind the cells together. occluding junctions (zonula occludens or tight junctions) adhering junctions (zonula adherens). desmosomes (macula adherens).
What is gap junction and tight junction?
Tight junction refers to a specialized connection of two adjacent animal cell membranes, such that, space usually lying between them is absent while a gap junction refers to a linkage of two adjacent cells consisting of a system of channels extending across a gap from one cell to the other, allowing the passage.
Where is occludin located?
Occludin is a 65-kD transmembrane protein located at TJ margins13,96 that is associated with cytoskeletal signaling proteins, including ZO-1 and ZO-2.