What is the tin man syndrome?

What is the tin man syndrome?

The patients suffered spasms triggered by startles from voluntary movement, touch, or emotional stress. This startle, stiffening, and fall response earned the nicknames tin-man syndrome and stiff-man syndrome.

What are the symptoms of heavy metal poisoning?

What are the symptoms of heavy metal poisoning?

  • diarrhea.
  • nausea.
  • abdominal pain.
  • vomiting.
  • shortness of breath.
  • tingling in your hands and feet.
  • chills.
  • weakness.

How is stiff-man syndrome diagnosed?

A definitive diagnosis can be made with a blood test that measures the level of glutamic acid decarboxylase (GAD) antibodies in the blood. People with SPS have elevated levels of GAD, an antibody that works against an enzyme involved in the synthesis of an important neurotransmitter in the brain.

What are the first symptoms of stiff person syndrome?

Symptoms include pain, muscle stiffness and aching discomfort. Early on, stiffness may come and go but eventually the stiffness remains constant. Over time, leg muscles become stiff and more muscles throughout your body become stiff including the arms and even the face.

What are the symptoms of SPS?

Summary. Stiff person syndrome (SPS) is a rare, progressive syndrome that affects the nervous system, specifically the brain and spinal cord. Symptoms may include extreme muscle stiffness, rigidity and painful spasms in the trunk and limbs, severely impairing mobility. Spasms can generate enough force to fracture bone.

Is Stiff Man Syndrome fatal?

Stiff person syndrome (SPS) is considered dangerous in babies because they generally meet unfortunate and untimely death within a few months. The normal lifespan of a grown adult can be stated as 50 years (if symptoms start early).

How do you treat heavy metal toxicity?

Three common drugs for treatment of metal poisoning are: BA. (Dimercaprol), Calcium EDTA (Calcium Disodium Versenate) and Penicillamine. Each of these work by binding actions that permit the metals to be eliminated from the body through the urine. Treatment should also be symptomatic and supportive.

What is the average life expectancy of someone with stiff person syndrome?

What is the life expectancy of a patient with stiff person syndrome? The life expectancy for people with SPS ranges from 6 to 28 years from the onset of the condition.

Does stiff person syndrome affect the brain?

Stiff person syndrome (SPS) is a rare, progressive syndrome that affects the nervous system, specifically the brain and spinal cord. Symptoms may include extreme muscle stiffness, rigidity and painful spasms in the trunk and limbs, severely impairing mobility.

Do all patients with SPS have diabetes?

It has been shown that ~45% of patients with SPS have type 1 diabetes (T1D), which is an autoimmune disease characterized by the immune-mediated loss of the insulin-producing pancreatic beta cells (1, 5, 8, 9).