What is the treatment for ER PR positive HER2-negative breast cancer?
What is the treatment for ER PR positive HER2-negative breast cancer?
General considerations – For women with early, estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer, adjuvant endocrine therapy is the mainstay of systemic treatment.
Is chemo recommended for HER2-negative?
Many women with hormone-positive, HER2-negative, lymph node-negative early-stage breast cancer who have intermediate risk of cancer recurrence do not need chemotherapy. The exception is that some women who are younger than 50 may benefit when chemotherapy is added to hormone therapy.
Do you need chemo if you are HER2-positive?
Because HER2-positive cancer is considered more aggressive than HER2-negative breast cancer, it is usually treated with chemotherapy after surgery to reduce recurrence risk.
Can you be ER and PR negative and HER2-positive?
Group 2 (luminal B). This type includes tumors that are ER positive, PR negative and HER2 positive.
Does chemotherapy work for estrogen positive breast cancer?
If you’re age 70 or older, have been diagnosed with estrogen-receptor-positive, HER2-negative, node-positive breast cancer, and have other serious medical conditions, this study offers some good news. Being treated with chemotherapy after breast cancer surgery may improve your survival.
Is it better to have ER PR positive or negative?
Tumors that are ER/PR-positive are much more likely to respond to hormone therapy than tumors that are ER/PR-negative. You may have hormone therapy after surgery, chemotherapy, and radiation are finished. These treatments can help prevent a return of the disease by blocking the effects of estrogen.
What chemo is used for HER2-positive?
Trastuzumab (Herceptin) and pertuzumab (Perjeta) are the most commonly used drugs used to treat HER2-positive breast cancer. Neratinib (Nerlynx) is another drug that is sometimes given after trastuzumab.
Can you be ER PR and HER2-positive?
Triple-positive cancers are ER-positive, PR-positive, and HER2-positive. These cancers can be treated with hormone drugs as well as drugs that target HER2.
Why would chemo not be an option?
Because of chemotherapy’s considerable side effects, it may not be safe for individuals who have underlying conditions. If your oncologist worries that your body is not strong enough to withstand chemotherapy, they will likely recommend other treatment options.